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The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.

✍ Scribed by Michael D. Mullican; David J. Lauffer; Roger J. Gillespie; Saroop S. Matharu; David Kay; Geoffrey M. Porritt; Phillip L. Evans; Julian M.C. Golec; Mark A. Murcko; Yu-Ping Luong; Scott A. Raybuck; David J. Livingston

Book ID: 103982815
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 306 KB
Volume: 4
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(94)85040-2

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✦ Synopsis

The tetrapeptide aldehyde AC-Tyr-Val-Ala-AspH (1, L-709,049) has been reported to be a potent reversible inhibitor of Interleukln-1 B Converting E e (ICE). We have prepared a series of analogs of 1, in order to explore the active site of ICE. The e ects of truncation, methylation of the amide nitrogens and "x" modification of the aldehyde group of 1 are presented.

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