✦ LIBER ✦

Enzymatic synthesis of peptidyl amino alcohols and peptidyl amino aldehydes-serine proteinase inhibitors

✍ Scribed by Joanna V. Potetinova; Tatiana L. Voyushina; Valentin M. Stepanov

Book ID: 104364903
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 256 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00091-7

No coin nor oath required. For personal study only.

✦ Synopsis

An enzymatic synthesis of peptidyl amino alcohols is described. The reactions were performed in organic solvents using as a catalyst subtilisin distributed on the surface of macroporous silica. Subsequent mild oxidation of peptidyl amino alcohols results in peptide aldehydes -the potent specific inhibitors of serine proteinases.

📜 SIMILAR VOLUMES

ChemInform Abstract: Enzymatic Synthesis

ChemInform Abstract: Enzymatic Synthesis of Peptidyl Amino Alcohols and Peptidyl Amino Aldehydes - Serine Proteinase Inhibitors.

✍ J. V. POTETINOVA; T. L. VOYUSHINA; V. M. STEPANOV 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB

Synthesis of Fmoc-Protected β-Amino Alco

Synthesis of Fmoc-Protected β-Amino Alcohols and Peptidyl Alcohols from Fmoc-Amino Acid/Peptide Acid Azides.

✍ Vommina V. Suresh Babu; Kantharaju Kantharaju; Naremaddepalli S. Sudarshan 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

The synthesis and evaluation of peptidyl

The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.

✍ Michael D. Mullican; David J. Lauffer; Roger J. Gillespie; Saroop S. Matharu; Da 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 306 KB

The tetrapeptide aldehyde AC-Tyr-Val-Ala-AspH (1, L-709,049) has been reported to be a potent reversible inhibitor of Interleukln-1 B Converting E e (ICE). We have prepared a series of analogs of 1, in order to explore the active site of ICE. The e ects of truncation, methylation of the amide nitrog

ChemInform Abstract: Simple and Efficien

ChemInform Abstract: Simple and Efficient Synthesis of Fmoc/Boc/Cbz-Protected-β-amino Alcohols and Peptidyl Alcohols Employing Boc2O.

✍ H. S. Lalithamba; Vommina V. Sureshbabu 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

Chirospecific synthesis of amino acids,

Chirospecific synthesis of amino acids, amino aldehydes and amino alcohols from D-glucosamine hydrochloride. A multigram synthesis of N-boc-L-serinal

✍ Athanassios Giannis; Thomas Henk 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 229 KB

Efficient Synthesis of New Peptidyl Chlo

Efficient Synthesis of New Peptidyl Chloromethyl Ketones for the Application of Proteinase K Inhibitors

✍ Kore, Anilkumar R.; Shanmugasundaram, Muthian 📂 Article 📅 2012 🏛 Taylor and Francis Group 🌐 English ⚖ 263 KB