The synthesis and characterization of [18F]-labeled fluoroamines
β Scribed by J. J. Posakony; T. J. Tewson
- Book ID
- 112132784
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 97 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
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Several nucleoside analogues like l-(~-D-glucopyranosyl)-5-fluorouracil 10, 1-(~-D-galactopyranosy1)-5-fluorouracil 11 and l-(2-deoxy-PD-glucopyranosyl)-5-fluorouracil 12 have been synthesized. From the corresponding 1-(2',3',4',6-tetra-O-acetyl-~-D-glycop~anosyl)-uracils 4, 5 and 6, the I8F labell
A oneβstep ^18^Fβlabelling strategy was used to prepare three labelled analogues of the vitamin biotin, which can be useful as tracers because of biotin's high affinity for avidin. The labelled compounds were obtained in decayβcorrected yields of up to 35% and specific radioactivity of 320βGBq/Β΅mol.