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The syntheses of [14C] and [13C4]pyromellitic acid

✍ Scribed by Nick Shipley; Kenneth W. M. Lawrie


Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
66 KB
Volume
50
Category
Article
ISSN
0022-2135

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πŸ“œ SIMILAR VOLUMES


Syntheses of [4-14c] and [6-14c]nisoldip
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## The synthesis of [ 4-14C]nisoldipine started from dimethyl [ 14C] formamide which was allowed to react with 2-nitrophenyllithium yielding 2-nitro [ 7-14C] benzaldehyde . Knovenagel condensation with isobutyl acetoacetate yielded isobutyl 2-(2-nitr0[7-~~C]benzylidene) acetoacetate. Key reaction

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## Abstract In support of a program to develop a treatment for chemotherapy‐induced nausea and vomiting, two isotopically labeled forms of neurokinin‐1 receptor antagonist aprepitant have been synthesized. A [^l4^C]‐labeled version was synthesized for use in metabolism studies, while a [^13^C~2~,^1

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The enzyme catalyzed displacement o f the methyl s u l f o n y l group from pentachlorophenyl methyl sulfone, the pchloroperoxybenzoic a c i d oxidation of methyl mercaptan and the reaction o f m e t h y l l i t h i u n with sulfur dioxide are methods described f o r the synthesis o f i s o t o p i