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The Surface Modification of Hydroxyapatite Nanoparticles by the Ring Opening Polymerization of γ-Benzyl-L-glutamate N-carboxyanhydride

✍ Scribed by Junchao Wei; Aixue Liu; Lei Chen; Peibiao Zhang; Xuesi Chen; Xiabin Jing

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
670 KB
Volume
9
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

The surface modification of hydroxyapatite (HA) nanoparticles by the ring opening polymerization (ROP) of γ‐benzyl‐L‐glutamate N‐carboxyanhydride (BLG‐NCA) was proposed to prepare the poly(γ‐benzyl‐L‐glutamate) (PBLG)‐grafted HA nanoparticles (PBLG‐g‐HA) for the first time. HA nanoparticles were firstly treated by 3‐aminopropylthriethoxysilane (APS) and then the terminal amino groups of the modified HA particles initiated the ROP of BLG‐NCA to obtain PBLG‐g‐HA. The process was monitored by XPS and FT‐IR. The surface grafting amounts of PBLG on HA ranging from 12.1 to 43.1% were characterized by thermal gravimetric analysis (TGA). The powder X‐ray diffraction (XRD) analysis confirmed that the ROP only underwent on the surface of HA nanoparticles without changing its bulk properties. The SEM measurement showed that the PBLG‐g‐HA hybrid could form an interpenetrating net structure in the self‐assembly process. The PBLG‐g‐HA hybrid could maintain higher colloid stability than the pure HA nanoparticles. The in vitro cell cultures suggested the cell adhesion ability of PBLG‐g‐HA was much higher than that of pure HA.

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