𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The random copolymerization of γ-benzyl-L-glutamate and L-valine N-carboxyanhydrides: Reactivity ratio and heteogeneity studies

✍ Scribed by W. Sederel; S. Deshmane; T. Hayashi; J. M. Anderson

Publisher
Wiley (John Wiley & Sons)
Year
1978
Tongue
English
Weight
785 KB
Volume
17
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The random copolymerization of the N‐carboxyhydrides of γ‐benzyl‐L‐glutamate and L‐valine using triethylamine as the initiator in low dielectric media reults in high‐molecular‐weight copolymers at low convenrson. This behavior makes it possible to apply the monomer reactivity ration theory, which was dervied for addition polymerizations, and from the use of the copolymer composition equation, the respective monomer reactivity ratios, the average and incremental copolymer compositions, and the monomer feed ratio at any conversion can be determined. A comparison of the reactivity ratios for the copolymerization of γ‐benzyl‐L‐glutamate NCA and L‐valine NCA in benzene/methylene chloride (r~G~ = 2.1, r~V~ = 0.6) with those obtained using dioxane (r~G~ = 2.7, r~V~ = 0.3) indicates that the interchain compositional heterogeneity is greater for copolymers prepared in the dioxane. For Example, at 100% conversion of the monomeric NCAs, Poly[Glu(OBzl)^50^Val^50^] prepared in dioxance has an interchain composition ranging from 74 to 0 mol % γ‐benzyl‐L‐glutamate, whereas in benzene/methylene chloride the interchain composition of γ‐benzyl‐L‐glutamae ranges from 65 to 0 mol %. Once the reactivity ratios are obtained for any pair of α‐amino and N‐carboxyanhydrides, the use of the aforementioned parameters relating to interchain composition can give insight into the compositional heterogeneity between chains as a function of conversion and provide a basis for the preparation of random α‐amino acid copolymers that are homogeneous.

📜 SIMILAR VOLUMES

Stereochemistry of the D and L copolymer
Stereochemistry of the D and L copolymerization of valine N-carboxyanhydride
✍ Toshihiro Akaike; Yukio Aogaki; Shohei Inoue 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 343 KB

## Abstract In the D and L copolymerization of valine __N__‐carboxyanhydride (NCA) with various D/L ratios initiated by __n__‐butylamine, the stereoselection of monomer NCA by the growing polymer chains, which take a β‐like conformation, does not take place. This result is in remarkable contrast to

The infuence of interchain compositional
The infuence of interchain compositional heterogeneity on the conformation in random copolymers of γ-benzyl-L-glutamate and L-valine
✍ S. Deshmane; T. Hayashi; W. Sederel; J. M. Anderson 📂 Article 📅 1978 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 773 KB

## Abstract Variation in the solvent used for the copolymerization of γ‐benzyl‐L‐glutamate and L‐valine __N__‐carboxyanhydrides provides copolymers which have variable interchain compositions, and this variation in interchain compositional heterogeneity is reflected in the solid‐state conformations

Correlation between the sequence-length
Correlation between the sequence-length distribution and structure of statistical copolymers of L-valine and γ-benzyl-L-glutamate
✍ V. Saudek; J. Stejskal; P. Schmidt; K. Zimmermann; V. Škarda; P. Kratochvíl; J. 📂 Article 📅 1987 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 1017 KB

Statistical copolymers were prepared from N-carboxyanhydrides of L-valine and y-benzyl-L-glutamate in dioxan with triethylamine as an initiator. The copolymerization conversion was determined by ir spectroscopy, the copolymer composition by amino acid analysis, and the molecular weights by light sca

Effect of Temperature on the Mobility of
Effect of Temperature on the Mobility of Core-Shell-Type Nanoparticles Composed of Poly(γ-benzyl-L-glutamate) and Poly(N-isopropylacrylamide)
✍ Mi Kyong Yoo; Mi Kyeong Jang; Jae Woon Nah; Mi Ran Park; Chong Su Cho 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB

## Abstract Summary: Core‐shell‐type nanoparticles composed of PBLG and PNIPAAm were prepared in an attempt to study the effects of temperature on the dynamic behavior of temperature‐sensitive polymeric shell, PNIPAAm, in the nanoparticles by ^1^H NMR spectroscopy. Spin‐lattice relaxation time (__T

Novel core-shell type thermo-sensitive n
Novel core-shell type thermo-sensitive nanoparticles composed of poly(γ-benzyl L-glutamate) as the core and poly(N-isopropylacrylamide) as the shell
✍ Chong-Su Cho; Jae-Bok Cheon; Young-Il Jeong; In-Sook Kim; Sung-Ho Kim; Toshihiro 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 497 KB

## Abstract AB diblock copolymers consisting of PBLG as the hydrophobic part and PNIPAAm as the hydrophilic one were prepared by polymerization of BLG‐NCA with semitelechelic PNIPAAm with amino end group as initiator. The core‐shell type nanoparticles of the block copolymers were obtained by the di