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The structure of the transition state in nucleophilic addition reactions to carbonyl compounds.

✍ Scribed by P. Geneste; G. Lamaty; J-P. Roque

Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
216 KB
Volume
11
Category
Article
ISSN
0040-4039

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✦ Synopsis

We have been interested for some time in the nucleophilic addition reactions to carl-6 bony1 compounds , the interpretation of our kinetic data has lead us to conclude that the position of the transition state along the reaction coordinate is not the same for all reactions and depends instead upon the nucleophilic reagent. This point, however, is a matter of controversy among workers in this field ; the "old" dichotomy first proposed by DAUBhN7 -Steric approach control versus product development control -nas been sharply criticized in recent years 8-12 and CHEREST and FELKIN 12 have postulated

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