The Enantioselective Addition of Alkyne Nucleophiles to Carbonyl Groups

✍ Scribed by Barry M. Trost; Andrew H. Weiss

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 506 KB
• Volume: 351
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200800776

✦ Synopsis

Abstract

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Over the past decade, large strides have been achieved in the invention of methods for the direct enantioselective addition of alkynes and metal alkynylide nucleophiles into prochiral aldehydes, ketones, and imines. This review highlights and compares the available methods for these transformations.