✦ LIBER ✦

The structure of the mammalian centromere

✍ Scribed by Jerome B. Rattner

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 719 KB
Volume: 13
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950130202

No coin nor oath required. For personal study only.

✦ Synopsis

The mammalian centromere is a multifunctional chromosomal domain with a complexity that is reflected in its higher order structure, DNA sequence organization and protein composition. The centromere plays a major role during cell division where it functions as the site for the integration of the chromosome with the mitotic spindle, the site of the mechanochemical motor responsible for the movement of chromosomes and the major and last point of interaction between sister chromatids. Recent studies have focused on characterizing the components of the centromere and establishing their relationship to its function. The following brief review summarizes some selected aspects of this recent work.

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