summahy: A phoc&5b 6vh the conucuion 06 methyL pneudomanate C to pbeudamotic acid A tuLth pardid m..mwk.civ~q .LA debchibed.
The structure and configuration of pseudomonic acid C
β Scribed by J.Peter Clayton; Peter J. O'Hanlon; Norman H. Rogers
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- French
- Weight
- 228 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
SUMHARY: A new antibiotic, pseudomonic aoid C (2a), has been isolated from fermentations
π SIMILAR VOLUMES
The synthesis of the cis-fused y-lactone 2,7-dioxabicycle-&3,4 non-4-en-g-one (3) by two routes is reported. Its stereoselective conversion to a key intermediate for pseudomonic acid synthesis is described.
## Tn8mmusTuYa? ?swmammc ACID+. PART 91. uumcrI(II, m9lmsxa Am mmAmlm a? mE c-13
The pseudomonic acid C analogue 19 can be readily constructed using a novel tandem methodology involving, as a key-step, an ene-reaction followed by a concomitant Intramolecular Silyl-Mediated Sakurai (ISMS) cyclisatlon.
A diastereocontrolled synthesis of the tetrahydropyran nucleus of pseudomonic acids has been achieved starting from a chiral building block, which we have developed. The key step is a convex-face reduction of the block having a biased framework which allowed assemblage of the most important core in