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A diastereocontrolled route to the tetrahydropyran nucleus of pseudomonic acids

✍ Scribed by Takahiko Taniguchi; Kunio Ogasawara

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
64 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A diastereocontrolled synthesis of the tetrahydropyran nucleus of pseudomonic acids has been achieved starting from a chiral building block, which we have developed. The key step is a convex-face reduction of the block having a biased framework which allowed assemblage of the most important core in a completely diastereoselective manner.

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