## Abstract A practical synthesis of (2R)‐ and (2S)‐[2‐^3^H]‐propionic acid is described. The key steps in the synthesis are the reduction of [__formyl__‐^3^H]‐3‐methoxy‐4‐mesyloxybenzaldehyde with R‐ or S‐Alpine Borane to (7S)‐ and (7R)‐[7‐^3^H]‐3‐methoxy‐4‐mesyloxybenzyl alcohol and the use of th
The stereospecific synthesis of (S)-2-[2H3]methyl-2-methylbutanol. characterisation of the (R) and (S) enantiomers of the racemic [2H3]alcohol by 2H-NMR in the presence of a chiral shift reagent.
✍ Scribed by David M. Harrison; Philip Quinn
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 227 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract Enantiomers of metoprolol containing six deuterium atoms in the isopropyl methyl groups were prepared in two steps from the sodium salt of 4‐(2‐methoxyethyl)phenol (3) and the commercially available (2__R__)‐ and (2__S__)‐glycidyl 3‐nitrobenzenesulfonates [(2__R__)‐2 and (2__S__)‐2]. Th
Borohydride reduction of the (+)-1,t-dehydrosparteiniuni salts 2a,b proceeds almost exclusively from the Si side, yielding, respectively, the stereoselectively (2S)(J)-deuterated (-)-sparteine l c from 2a and NaB2H,, and the (tR)(a)-deuterated (-)-sparteiite Id from 2b and NaBH,. Stereochemistry and