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The stereoselective synthesis of cyclopropylphosphonate analogs of nucleotides

✍ Scribed by Jung Hwan Hah; Jun Mo Gil; Dong Young Oh

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 325 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01747-5

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✦ Synopsis

1-Alkenylphosphonic acid derivatives of purines have been proven to exhibit significant antiviral activity among these series of compounds. Here we disclose the stereoselective synthesis of the constrained analogs of 1-alkenylphosphonate derivatives of purines via intramolecular epoxide opening reaction of \d,6epoxyalkanephosphonates with subsequent Mitsunobu coupling reactions with purine bases.

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