A new scheme for the synthesis of 5′-nucleotide phosphonate analogs
✍ Scribed by Nelly Sh Padyukova; Marat Ya Karpeisky; Lidiya I Kolobushkina; Sergey N Mikhailov
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 234 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A convenient and general method is proposed for the synthesis of 5*-nucleotide phosphonate analogs starting from 5-deoxy-1,2-0isopropylidene-d-D-xylo-hexofuranose (I).
📜 SIMILAR VOLUMES
Phosphonate compounds mimic the first transition state from a C-4 chiral synthon, 3-buten-1,2-diol -and treated with n-pentylphosphonic dichloride and p-nitrophenol to occurring during enzymatic carboxyester hydrolysis of natural substrates by forming a covalent bond with the afford the correspondin
Various approaches leading to mono-, di-, and polyfunctionalized phosphonates as well as phosphoryl heterocycles are reported for the systematic study of relationships between chemical structure and biological activity of this most important class of organophosphorus compounds.