The stereoselective preparation of β-hydroxy esters using a yeast reduction in an organic solvent

✍ Scribed by Caroline Medson; Andrew J. Smallridge; Maurie A. Trewhella

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 378 KB
• Volume: 8
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(97)00050-5

✦ Synopsis

A range of (S)-p-hydroxy esters has been prepared in high yield (X&96%) and with very high enantioselectivity (>94%) using a yeast mediated reduction in light petroleum. It was found that the ester functionality had a marked effect on both the isolated yield and the quantity of yeast required to effect complete reduction. @