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The Stepwise Solid-Phase Synthesis Methodology is Suitable for the Preparation of a Great Variety of Nucleopeptides

✍ Scribed by Marchán, V.; Debéthune, L.; Beltrán, M.; Robles, J.; Travesset, I.; Fábregas, G.; Pedroso, E.; Grandas, A.


Book ID
126887673
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
143 KB
Volume
18
Category
Article
ISSN
0732-8311

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Three peptide-oligonucleotide phosphorothioate hybrids were synthesized using a new approach for stepwise solidphase synthesis of conjugates. This method utilizes commercially available N a -Fmoc amino acids for peptide synthesis and a new solid support. Three specific modifications of the solid-pha