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The spleen in the wiskott-aldrich syndrome: White pulp changes correlate with the clinical phenotype of the disease

✍ Scribed by F. Facchetti; W. Vermi; L. Blanzuoli; P.G. Grigolato; F. Donato; S. Giliani; L.D. Notarangelo


Book ID
117326088
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
299 KB
Volume
35
Category
Article
ISSN
0161-5890

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Wiskott-Aldrich syndrome is an X-linked disorder characterized by thrombocytopenia, eczema and immunodeficiency. The Wiskott-Aldrich syndrome protein and the gene that encodes it have been identified by positional cloning and the protein has been shown to contain a pleckstrin-homology domain, a GTPa