Phenotypic perturbation of B cells in the Wiskott–Aldrich syndrome
✍ Scribed by J. Y. Park; A. Shcherbina; F. S. Rosen; A. P. Prodeus; E. Remold-O’Donnell
- Book ID
- 110090415
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 321 KB
- Volume
- 139
- Category
- Article
- ISSN
- 0009-9104
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The Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive disorder characterized by eczema, thrombocytopenia, and immunodeficiency. An allelic variant of the disease is characterized by isolated thrombocytopenia (XLT). The gene responsible for WAS/XLT (WASP) encodes for a 502 amino acid protei
Wiskott-Aldrich syndrome is an X-linked disorder characterized by thrombocytopenia, eczema and immunodeficiency. The Wiskott-Aldrich syndrome protein and the gene that encodes it have been identified by positional cloning and the protein has been shown to contain a pleckstrin-homology domain, a GTPa
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