The fact that enzyme complexes, stable, quasi-stable, and dynamic, exist in cells can no longer be ignored. Experimental evidence done with a variety of techniques has demonstrated these interactions in vitro and in vivo. There is scarcely a single known metabolic pathway in which no interactions of
The specificity of steroid-enzyme interactions
โ Scribed by Paul Talalay
- Publisher
- John Wiley and Sons
- Year
- 1957
- Tongue
- English
- Weight
- 318 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0008-543X
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## Abstract __We analyzed the binding of five steroids to the human glucocorticoid receptor (hGR) experimentally as well as theoretically. In vitro, we measured the binding affinity of aldosterone, cortisol, estradiol, progesterone, and testosterone to hGR in competition with the ligand dexamethaso