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The solid-state synthesis of tritium labelled heterocyclic bases

✍ Scribed by Georgy V. Sidorov; Nikolai F. Myasoedov

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
225 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The results of a study of. the solid‐state catalytic hydrogenation and the synthesis of tritium labelled native heterocyclic bases are presented. The effect of different palladium catalysts and reaction conditions on yield and molar radioactivity of final compounds was investigated. For some compounds, data on the intramolecular distribution of tritium were obtained by using the isotope exchange reaction and tritium NMR. Tritium labelled purine and pyrimidine bases (25–180 Ci/mmol.) were synthesized.

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