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The solid phase synthesis of oligoureas

โœ Scribed by Jong-Man Kim; Yingzhi Bi; Sari J. Paikoff; Peter G. Schultz


Book ID
103410627
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
222 KB
Volume
37
Category
Article
ISSN
0040-4039

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A procedure for the solid-phase synthesis of oligourea acids with UV irradiation when a photocleavable linker is used or as C-terminal hydantoins with 10% TEA/MeOH and peptidomimetics starting from Boc-protected monomers is described. The compounds are prepared on Tentagel ยฎ resin a catalytic amount

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This paper reports an efficient synthesis of N-alkyI-N,N'-Iinked oligoureas [-NR-CO-NH-CH2CH2-]n, which involves the repetition of three steps: (1) main-chain extension by ring-opening of N-(2-nitrobenzenesulfonyl)-2-imidazolidone (1) by a secondary amine RR'NH to afford sulfonamide RR'N-CO-NH-CH2CH