The solid phase synthesis of oligoureas
โ Scribed by Jong-Man Kim; Yingzhi Bi; Sari J. Paikoff; Peter G. Schultz
- Book ID
- 103410627
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 222 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
A procedure for the solid-phase synthesis of oligourea acids with UV irradiation when a photocleavable linker is used or as C-terminal hydantoins with 10% TEA/MeOH and peptidomimetics starting from Boc-protected monomers is described. The compounds are prepared on Tentagel ยฎ resin a catalytic amount
This paper reports an efficient synthesis of N-alkyI-N,N'-Iinked oligoureas [-NR-CO-NH-CH2CH2-]n, which involves the repetition of three steps: (1) main-chain extension by ring-opening of N-(2-nitrobenzenesulfonyl)-2-imidazolidone (1) by a secondary amine RR'NH to afford sulfonamide RR'N-CO-NH-CH2CH