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Microwave-Enhanced Solid-Phase Synthesis of N , N′ -Linked Aliphatic Oligoureas and Related Hybrids

✍ Scribed by Douat-Casassus, Céline; Pulka, Karolina; Claudon, Paul; Guichard, Gilles

Book ID
117995689
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
616 KB
Volume
14
Category
Article
ISSN
1523-7060

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## Abstract Structural modification of the peptide backbone via __N__‐methylation is a powerful tool to modulate the pharmacokinetic profile and biological activity of peptides. Here we describe a rapid and highly efficient microwave(MW)‐assisted Fmoc/tBu solid‐phase method to prepare short chain _