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Solid-Phase Synthesis of Oligourea Peptidomimetics

✍ Scribed by Astrid Boeijen; Rob M. J. Liskamp

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
291 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

A procedure for the solid-phase synthesis of oligourea acids with UV irradiation when a photocleavable linker is used or as C-terminal hydantoins with 10% TEA/MeOH and peptidomimetics starting from Boc-protected monomers is described. The compounds are prepared on Tentagel ® resin a catalytic amount of KCN. and can be obtained selectively either as the C-terminal free domimetics, employing phthalimide-protected isocyanates [a]

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