THE SMALL-SCALE SYNTHESIS OF 13C-18ARELLED DICHLOROMETHV, PHOSPHIXE (METHYLPHOPPHONOUS DICHLORIDE) I a J.Colqutboun and :I .Plck'arlane, Department of Chemistry, C i t y o f London Polytechnic, London 5X3N 2EY, tingland.
The small-scale synthesis of 13C-labelled methyltin iodides
β Scribed by Dr. J. D. Kennedy
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- French
- Weight
- 92 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
β¦ Synopsis
In connection'with other studies, we have synthesised methyltin triiodide and trimethyltin iodide enriched with I3C in the methyl groups. methods of equations ( 1)-( 4) and ( 5) were adequate, and the most satisfactory procedures were as described below.
The SnC12
π SIMILAR VOLUMES
12 '-13C] aZZ-rac-a-Tocopherol (L) was synthesized from [2-13C] acetone. The condensation of 6-methoxymethoxy-2,5,7,8-tetramethyl-2-(5-mercaptothiazolinyl-4-methyl-3-penten-1-y1)chroman (S) with [7-Clgeranyl bromide (11, which was prepared by the coupling of (6-benzoyloxy--4-methyl-4-hexenyl)triphen
## Abstract A practical synthetic laboratory route for the synthesis of trideuteriomethylβ[^13^C] iodide (^13^CD~3~I) (from tetradeuterioβ[^13^C]βmethanol and hydriodic acid) is described. We comment on the experimental protocol, and the use of water as an βadditiveβ to improve the synthetic yield.
DNA / Dihydroxyacetone monophosphate
2-hydroxy-2-methyl-4-phenyl-3,4-dihydro-2β¬J,5~pyrano[3,2-cl[l]benzopyran-5-one IS labeled with 98+% 13C at the anomeric carbon (C2) and resolved 4-phenyl-3-buten-2-one-2-13C(98+%). Michael-type addition of this to 4-hydroxycoumarin in methanol produces the labeled diastereomeric warfarin methyl keta