The silence of the genes: Matching mismatch repair defects with tumors

✍ Scribed by C. Richard Boland; Ajay Goel

• Book ID: 102105252
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 51 KB
• Volume: 98
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/cncr.11769

✦ Synopsis

Research over the past 20 years has shown that all cancers are diseases of genes. However, the genetic pathways to tumor development are complex and variable. Much of the work in the past decade has been to identify the pathways of development for tumors in individual organs, and to translate these findings into improved methods for the prevention and treatment of malignancies. In this issue of Cancer, Geisler et al. report the role of epigenetic silencing of the hMLH1 and hMSH2 genes in the genesis of ovarian carcinoma