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The natural history of adenomas associated with germline defects in DNA mismatch-repair genes

✍ Scribed by De Jong, Andrea E.; Morreau, Hans; Nagengast, Fokko M.; Griffioen, Gerrit; Cats, Annemieke; Menko, Fred H.; Kleibeuker, Jan H.; Vasen, Hans F.A.


Book ID
123007483
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
169 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Communicated by Riccardo Fodde Numerous unclassified variants (UVs) have been found in the mismatch repair genes MLH1 and MSH2 involved in hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Some of these variants may have an effect on pre-mRNA splicing, either by altering dege