Effect of nifedipine in metastatic colon cancer with DNA mismatch repair gene defect
β Scribed by Jia-Lin Yang; Michael L Friedlander
- Book ID
- 117277225
- Publisher
- The Lancet
- Year
- 2001
- Tongue
- English
- Weight
- 250 KB
- Volume
- 357
- Category
- Article
- ISSN
- 0140-6736
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Hereditary nonpolyposis colorectal cancer (HNPCC) is a common autosomal dominant disease caused by germline mutations in DNA mismatch repair genes. The mutational spectrum in these genes appears to be diverse, in both the distribution and the nature of the mutations. However, most described mutation
## Abstract ## BACKGROUND: Colon cancers with defective DNA mismatch repair (MMR) have a favorable prognosis and may lack benefit from 5βfluorouracilβbased adjuvant chemotherapy. The authors developed models to predict MMR deficiency in sporadic colon cancer patients using routine clinical and pat