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Defective DNA Mismatch Repair Determines a Characteristic Transcriptional Profile in Proximal Colon Cancers

✍ Scribed by Massimiliano di Pietro; Jacob Sabates Bellver; Mirco Menigatti; Fridolin Bannwart; Annelies Schnider; Anna Russell; Kaspar Truninger; Josef Jiricny; Giancarlo Marra


Book ID
119758660
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
636 KB
Volume
129
Category
Article
ISSN
0016-5085

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✍ Frank Sinicrope; Nathan R. Foster; Daniel J. Sargent; Stephen N. Thibodeau; Thom πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 149 KB

## Abstract ## BACKGROUND: Colon cancers with defective DNA mismatch repair (MMR) have a favorable prognosis and may lack benefit from 5‐fluorouracil–based adjuvant chemotherapy. The authors developed models to predict MMR deficiency in sporadic colon cancer patients using routine clinical and pat