𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The significance of unstable chromosomes in colorectal cancer

✍ Scribed by Rajagopalan, Harith; Nowak, Martin A.; Vogelstein, Bert; Lengauer, Christoph

Book ID
109947011
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
162 KB
Volume
3
Category
Article
ISSN
1474-1776

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✦ Synopsis

A very large fraction of cancers have an abnormal genetic content, called aneuploidy, which is characterized by changes in chromosome structure and number. One explanation for this aneuploidy is chromosomal instability, in which cancer cells gain or lose whole chromosomes or large fractions of chromosomes at a greatly increased rate compared with normal cells. Here, we explore experimental and theoretical evidence for the initiation of chromosomal instability in very early colorectal cancers, and reflect on the role that chromosomal instability could have in colorectal tumorigenesis.

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## Abstract Colorectal cancers (CRC) develop through 2 major pathways of genetic instability. In contrast to the majority of CRCs, which are characterized by chromosomal instability, high‐level microsatellite unstable (MSI‐H) CRCs arise as a consequence of the loss of DNA mismatch repair (MMR) func