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The significance of unstable chromosomes in colorectal cancer

✍ Scribed by Rajagopalan, Harith; Nowak, Martin A.; Vogelstein, Bert; Lengauer, Christoph

Book ID
109947010
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
162 KB
Volume
3
Category
Article
ISSN
1474-1776

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## Abstract Colorectal cancers (CRC) develop through 2 major pathways of genetic instability. In contrast to the majority of CRCs, which are characterized by chromosomal instability, high‐level microsatellite unstable (MSI‐H) CRCs arise as a consequence of the loss of DNA mismatch repair (MMR) func