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The significance of new abnormal isoenzymes of 5′-nucleotide phosphodiesterase in the diagnosis of human liver cancer

✍ Scribed by Ke-Min Lin; Si-Yuan Ye; Qi-Fu Liu

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
293 KB
Volume
41
Category
Article
ISSN
0020-7136

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✦ Synopsis

In 1986, we reported that abnormal 5'-nucleotide phosphodiesterase (5'-NP) (oligonucleate: 5'-nucleotidohydrolase, EC 3.1.4.1) isoenzymes (5'-NP I and 5'-NP V +VI) were observed in the serum of patients with liver cancer. The results of the present study show that the 5'-NP I positivity rate is 99.2Yo (234/236), specificity 74.9C; and the 5'-NP V + Vl positivity rate is 77.5% (183/236), specificity 95.3% in liver cancer. 5'-NP I positivity rate is 86.7% (13/15) and 5'-NP V + V I positivity rate is 46.7% (7/15) in metastatic liver cancer. These 3 abnormal isoenzyme bands were all present in the serum of 6 patients with liver cancer before radical resection and disappeared after successful resection, but they were all present in the serum of 6 other liver cancer patients before and after palliative operation. In 2 cases of small liver cancer (diameter less than 4cm), 5'-NP I and 5'-NP V + V I were strongly positive. It may be considered that the new 5'-NP abnormal isoenzyme bands are specific markers and will be useful for diagnosis of human liver cancer.

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