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The significance of 5′-nucleotide phosphodiesterase isozymes in the diagnosis of liver carcinoma

✍ Scribed by H. M. Lu; C. Chen; P. C. Sze; T. H. Ming; K. L. Chiang; C. R. Ting; L. X. Pan; T. Y. Liu; C. Yiu

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
409 KB
Volume
26
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The results of determination of the serum 5′‐NPDase isozymes in 95 cases of primary liver carcinoma and other kinds of liver disase are presented. The 5′‐NPDase‐V was positive in 83.2% of primary liver cancer cases. This test might be a useful supplement to AFP determination, especially in AFP‐negative liver cancer patients. In most patients who had undergone successful liver resection for primary carconoma, the test became negative. A positive 5′‐NPDase‐V test in patients with cancers elsewhere in the body may suggest liver metastasis. In addition, this test may be of some help in the differentiation of primary liver cancer from other kinds of liver disease. The problem of “false‐positive” results of this test is discussed.

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