๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The shikimate pathway. Part 9. Halogenation at C-3 of the shikimate nucleus

โœ Scribed by Roger Brettle; Richard Cross; Martyn Frederickson; Edwin Haslam; Fiona S. MacBeath; Gareth M. Davies

Book ID
103398210
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
555 KB
Volume
52
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

New simplified inhibitors of EPSP syntha
New simplified inhibitors of EPSP synthase: The importance of ring size for recognition at the shikimate 3-phosphate site
โœ Mark L. Peterson; Susan D. Corey; Jose L. Font; Mark C. Walker; James A. Sikorsk ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 291 KB

The simple 4-[(a-hydroxy)phosphonomethyl]-lH-pyrrole-2-carboxylate 4 is a surprisingly good S3Panalog inhibitor of EPSP synthase (competitive with S3P, Ki(app) = 14.5 + 0.7 laM). The affinity of 4 for free enzyme is nearly comparable to that of S3P (K d = 7 + 1.2 IxM). Compound 4 thus represents the