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The separation of dihydrofolate reductase inhibitors and the determination of pKa,1 values by capillary zone electrophoresis

✍ Scribed by Jing Cao; Reginald F. Cross

Book ID
107785257
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
718 KB
Volume
695
Category
Article
ISSN
1873-3778

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Determination of pKa values by capillary
Determination of pKa values by capillary zone electrophoresis with a dynamic coating procedure
✍ Laurent Geiser; Yveline Henchoz; Alexandra Galland; Pierre-Alain Carrupt; Jean-L πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 465 KB πŸ‘ 1 views

CZE allows to measure the acidic dissociation constant (pKa) of many drug substances. However, determining the EOF intensity may be time-consuming, especially at a low pH. In order to overcome this drawback, a dynamic coating procedure of the capillary was carried out to increase microEOF, and thus