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The search for cerebral biomarkers of Huntington's disease: a review of genetic models of age at onset prediction

✍ Scribed by F. Squitieri; A. Ciarmiello; S. Di Donato; L. Frati

Book ID: 111064636
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 184 KB
Volume: 13
Category: Article
ISSN: 1351-5101
DOI: 10.1111/j.1468-1331.2006.01264.x

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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO ≥65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we