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Age at Onset: An Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease

✍ Scribed by KATRIN BEYER; JOSÉ I. LAO; PILAR LATORRE; AURELIO ARIZA


Book ID
111398386
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
955 KB
Volume
1057
Category
Article
ISSN
0890-6564

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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO ≥65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we