The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis
β Scribed by Ariyaratana, Suzie; Loeb, David M.
- Book ID
- 118182965
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 198 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1574-6976
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W T l , the Wilms' tumour suppressor gene located at chromosome llp13, plays an important role in the development of the kidney. It is mutated in 10 per cent of Wilms' tumours (WTs) and their putative precursors called nephrogenic rests (NRs). A sensitive immunohistochemical technique was establishe
## Abstract We report expression of the __wt__ I (Wilms' tumor) gene by cultured human melanoma cells. Using RNA polymerase chain reaction analysis, __wt__ I transcripts were detected in 7 of 9 melanoma cell lines but not in 5 normal melanocyte strains. In Northern blot analysis, steadyβstate __wt_