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The Wilms tumour gene,WT1, in normal and abnormal nephrogenesis

✍ Scribed by Kathryn Pritchard-Jones


Publisher
Springer
Year
1999
Tongue
English
Weight
350 KB
Volume
13
Category
Article
ISSN
0931-041X

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W T l , the Wilms' tumour suppressor gene located at chromosome llp13, plays an important role in the development of the kidney. It is mutated in 10 per cent of Wilms' tumours (WTs) and their putative precursors called nephrogenic rests (NRs). A sensitive immunohistochemical technique was establishe

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## Abstract Recurrent genetic aberrations are important predictors of outcome in acute myeloid leukaemia (AML). Numerous novel molecular abnormalities have been identified and investigated in recent years adding to the risk stratification and prognostication of conventional karyotyping. Mutations i

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## Abstract We report expression of the __wt__ I (Wilms' tumor) gene by cultured human melanoma cells. Using RNA polymerase chain reaction analysis, __wt__ I transcripts were detected in 7 of 9 melanoma cell lines but not in 5 normal melanocyte strains. In Northern blot analysis, steady‐state __wt_