W T l , the Wilms' tumour suppressor gene located at chromosome llp13, plays an important role in the development of the kidney. It is mutated in 10 per cent of Wilms' tumours (WTs) and their putative precursors called nephrogenic rests (NRs). A sensitive immunohistochemical technique was establishe
The Wilms tumour gene,WT1, in normal and abnormal nephrogenesis
β Scribed by Kathryn Pritchard-Jones
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 350 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0931-041X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The WT1 gene encodes a developmentally regulated transcription factor whose function is altered by alternative splicing at two sites: the 17 amino acids of exon 5, whose functional effects are ill-defined, and the 3 amino acids (KTS) between exons 9 and 10, which determine sequence-specific DNA bind
## Abstract Recurrent genetic aberrations are important predictors of outcome in acute myeloid leukaemia (AML). Numerous novel molecular abnormalities have been identified and investigated in recent years adding to the risk stratification and prognostication of conventional karyotyping. Mutations i
## Abstract We report expression of the __wt__ I (Wilms' tumor) gene by cultured human melanoma cells. Using RNA polymerase chain reaction analysis, __wt__ I transcripts were detected in 7 of 9 melanoma cell lines but not in 5 normal melanocyte strains. In Northern blot analysis, steadyβstate __wt_