Expression of the Wilms' tumour gene WT 1 in human malignant mesothelioma cell lines
✍ Scribed by Anthonie W. Langerak; Kathy Williamson; Klyoshi Miyagawa; Nicholas D. Hastie; Marian A. Versnel
- Book ID
- 119106397
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 96 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis
## Abstract We report expression of the __wt__ I (Wilms' tumor) gene by cultured human melanoma cells. Using RNA polymerase chain reaction analysis, __wt__ I transcripts were detected in 7 of 9 melanoma cell lines but not in 5 normal melanocyte strains. In Northern blot analysis, steady‐state __wt_