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The Wilms tumour gene WT1 is expressed in murine mesoderm–derived tissues and mutated in a human mesothelioma

✍ Scribed by Park, Seon; Schalling, Martin; Bernard, Amy; Maheswaran, Shyamala; Shipley, Gwen C.; Roberts, Drucilla; Fletcher, Jonathan; Shipman, Robert; Rheinwald, James; Demetri, George

Book ID: 109916653
Publisher: Nature Publishing Group
Year: 1993
Tongue: English
Weight: 928 KB
Volume: 4
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng0893-415

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Mutations in the WTI tumor suppressor gene are known t o contribute t o the development of Wilms' tumor (WT) and associated gonadal abnormalities. WTI is expressed principally in the fetal kidney, developing gonads, and spleen and also in the mesothelium, which lines the coelomic cavities. These tis