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The role of the CD4 (L3T4) molecule in T-cell activation

โœ Scribed by Burakoff, S.J.


Book ID
123535557
Publisher
Elsevier Science
Year
1987
Weight
400 KB
Volume
138
Category
Article
ISSN
0769-2625

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CD4, CD8 and the role of CD45 in T-cell
โœ Jeffrey A. Ledbetter; Julie P. Deans; Alejandro Aruffo; Laura S. Grosmaire; Stev ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 1009 KB

CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta