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The role of L3T4 (CD4) in T-Cell activation

✍ Scribed by Greenstein, J.L.; Burakoff, S.J.

Book ID
121955810
Publisher
Elsevier Science
Year
1987
Weight
774 KB
Volume
138
Category
Article
ISSN
0769-2625

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta