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The role of squalene synthetase in the inhibition of tetrahymanol biosynthesis by cholesterol inTetrahymena pyriformis

✍ Scribed by Colin F. Warburg; Marwa Wakeel; David C. Wilton


Book ID
112773271
Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
354 KB
Volume
17
Category
Article
ISSN
0024-4201

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TriΒ―uoromethyl ketones 1 and 2, have been prepared from trisnorsqualene aldehyde 3. These compounds and their corresponding alcohols 4 and 7 have been found to be good inhibitors of the biosynthesis of cholesterol in HepG2 cells. The inhibition is correlated with a decrease of the HMG-CoA reductase