Trifluoromethyl ketones derived from squ
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Farid Benayoud; Ahmed Abouabdellah; Cyrille Richard; Danièle Bonnet-Delpon; Jean
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Article
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2000
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Elsevier Science
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French
β 154 KB
TriΒ―uoromethyl ketones 1 and 2, have been prepared from trisnorsqualene aldehyde 3. These compounds and their corresponding alcohols 4 and 7 have been found to be good inhibitors of the biosynthesis of cholesterol in HepG2 cells. The inhibition is correlated with a decrease of the HMG-CoA reductase