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The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity

✍ Scribed by Richard P. Munton; Sándor Vizi; Isabelle M. Mansuy


Book ID
116464407
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
187 KB
Volume
567
Category
Article
ISSN
0014-5793

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Long-term potentiation (LTP) and long-term depression (LTD) are calcium-dependent forms of synaptic plasticity observed in area CA1 of the hippocampus. Low-frequency tetani (1-5 Hz) activates protein phosphatases to induce LTD, whereas high-frequency tetani (>25 Hz) activates protein kinases to indu