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Intra-spaced stimulation and protein phosphatase 1 dictate the direction of synaptic plasticity

✍ Scribed by David Genoux; Paula Bezerra; Johanna M. Montgomery

Book ID
109028579
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
534 KB
Volume
33
Category
Article
ISSN
0953-816X

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Protein kinase and phosphatase activity
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Long-term potentiation (LTP) and long-term depression (LTD) are calcium-dependent forms of synaptic plasticity observed in area CA1 of the hippocampus. Low-frequency tetani (1-5 Hz) activates protein phosphatases to induce LTD, whereas high-frequency tetani (>25 Hz) activates protein kinases to indu