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The Role of Physiologically Based Pharmacokinetic Modeling in Regulatory Review

✍ Scribed by Huang, S-M; Rowland, M


Book ID
119953811
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
343 KB
Volume
91
Category
Article
ISSN
0009-9236

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Physiologically based pharmacokinetic mo
✍ Kannan Krishnan; Lee C.B. Crouse; Matthew A. Bazar; Michael A. Major; Gunda Redd πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 369 KB

## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion‐lim