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Physiologically Based Pharmacokinetic Modeling at the Extremes of Age

✍ Scribed by Johnston, C; Kirkpatrick, C M; McLachlan, A J; Hilmer, S N


Book ID
120067402
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
79 KB
Volume
93
Category
Article
ISSN
0009-9236

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Physiologically based pharmacokinetic mo
✍ Kannan Krishnan; Lee C.B. Crouse; Matthew A. Bazar; Michael A. Major; Gunda Redd πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 369 KB

## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion‐lim