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Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions

✍ Scribed by Xia, Binfeng; Heimbach, Tycho; Lin, Tsu-han; He, Handan; Wang, Yanfeng; Tan, Eugene

Book ID
113028090
Publisher
Springer
Year
2012
Tongue
English
Weight
595 KB
Volume
69
Category
Article
ISSN
0344-5704

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## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusion‐lim