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The role of phospholipase D in Glut-4 translocation

✍ Scribed by Ping Huang; Michael A. Frohman

Book ID
102154987
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
103 KB
Volume
19
Category
Article
ISSN
1520-7552

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✦ Synopsis

Abstract

Insulin‐stimulated Glut‐4 translocation is regulated through a complex pathway. Increasing attention is being paid to the role undertaken in this process by Phospholipase D, a signal transduction‐activated enzyme that generates the lipid second‐messenger phosphatidic acid. Phospholipase D facilitates Glut‐4 translocation at potentially multiple steps in its outward movement. Current investigation is centered on Phospholipase D promotion of Glut‐4‐containing membrane vesicle trafficking and vesicle fusion into the plasma membrane, in part through activation of atypical protein kinase C isoforms. Copyright © 2003 John Wiley & Sons, Ltd.

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