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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

โœ Scribed by Chiang, Shian-Huey; Baumann, Christian A.; Kanzaki, Makoto; Thurmond, Debbie C.; Watson, Robert T.; Neudauer, Cheryl L.; Macara, Ian G.; Pessin, Jeffrey E.; Saltiel, Alan R.


Book ID
109774403
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
204 KB
Volume
410
Category
Article
ISSN
0028-0836

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Swiss 3T3 mouse fibroblasts were exposed to 10 microM colchicine to disrupt microtubules, then stimulated with insulin-like growth factor-I. Immunoprecipitation experiments showed that insulin-like growth factor-I receptor and insulin receptor substrate-1 were tyrosine phosphorylated to the same ext